N-demethylation of alkaloids using nanoscale zero valent iron

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dc.contributor.advisor Singer, Robert D. (Robert Douglas), 1964-
dc.creator Awalt, Jon Kyle
dc.date.accessioned 2016-06-10T13:49:08Z
dc.date.available 2016-06-10T13:49:08Z
dc.date.issued 2016
dc.identifier.uri http://library2.smu.ca/handle/01/26518
dc.description 1 online resource (x, 48 p.) : ill. (some col.)
dc.description Includes abstract.
dc.description Includes bibliographical references (p. 42-48).
dc.description.abstract The N-demethylation of naturally occurring opiate compounds is a necessary step in the synthesis of many pseudo-opioid pharmaceuticals. Such drugs have gained recent media attention in the fight against opiate addiction; hence, the ability to synthesize them efficiently is important. This work aims to improve the N-demethylation of alkaloid precursors through the use of zero valent nanoscale iron in a modified Polonovski reaction. Initial studies performed on dextromethorphan indicate that yields of the demethylated product using a 10 mol % loading of zero valent nanoscale iron are comparable to those achieved by using a stoichiometric amount of commercially available iron (0) dust. The preparation of zero valent nanoscale iron particles and their use in the N-demethylation of dextromethorphan will be described. en_CA
dc.language.iso en en_CA
dc.publisher Halifax, N.S. : Saint Mary's University
dc.title N-demethylation of alkaloids using nanoscale zero valent iron en_CA
dc.type Text en_CA
thesis.degree.name Bachelor of Science (Honours Chemistry)
thesis.degree.level Undergraduate
thesis.degree.discipline Chemistry
thesis.degree.grantor Saint Mary's University (Halifax, N.S.)


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