Investigating whether the FGF pathways are involved in scleral ossicle development

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dc.contributor.advisor Franz-Odendaal, Tamara
dc.creator Kumar, Shruti
dc.date.accessioned 2023-02-28T15:27:33Z
dc.date.available 2023-02-28T15:27:33Z
dc.date.issued 2017-08-09
dc.identifier.uri http://library2.smu.ca/xmlui/handle/01/31387
dc.description 1 online resource (xi, 213 pages) : illustrations (chiefly colour), charts (some colour), graphs (some colour)
dc.description Includes abstract and appendices.
dc.description Includes bibliographical references (pages 125-144).
dc.description.abstract During animal development, fibroblast growth factors (FGF) play several important roles. Both ‘b’ and ‘c’ isoforms of <i>fibroblast growth factor receptors</i> 1-3 were expressed in the conjunctival papillae, a ring of small epithelial thickenings in the corneal-scleral limbus that induce scleral ossicles, a ring of neural crest derived intramembranous bones in the chick sclera. Whereas, downregulation of the <i>FGFR</i> isoforms was observed during the later stages of scleral ossicle induction. All <i>FGFR</i> isoforms were expressed in the epithelium, however, only <i>FGFR</i>1c, 2c, 3b, and 3c were expressed in the mesenchyme. I also examined the potential role of the FGF pathway during scleral ossicle induction, however, these results were inconclusive. This research provides insight into the expression of another major developmental gene family that could play an important role in the scleral ossicle system and helps to further conceptualize the basic signalling networks involved during scleral ossicle formation. en_CA
dc.description.provenance Submitted by Greg Hilliard (greg.hilliard@smu.ca) on 2023-02-28T15:27:33Z No. of bitstreams: 1 Kumar_Shruti_MASTERS_2017.pdf: 4904479 bytes, checksum: 1f94684b8042cbad894f061bc88c86f9 (MD5) en
dc.description.provenance Made available in DSpace on 2023-02-28T15:27:33Z (GMT). No. of bitstreams: 1 Kumar_Shruti_MASTERS_2017.pdf: 4904479 bytes, checksum: 1f94684b8042cbad894f061bc88c86f9 (MD5) Previous issue date: 2017-08-09 en
dc.language.iso en en_CA
dc.publisher Halifax, N.S. : Saint Mary's University
dc.subject.lcsh Fibroblast growth factors
dc.subject.lcsh Sclera
dc.subject.lcsh Conjunctivitis
dc.subject.lcsh Epithelium
dc.subject.lcsh Mesenchyme
dc.subject.lcsh Genes
dc.title Investigating whether the FGF pathways are involved in scleral ossicle development en_CA
dc.type Text en_CA
thesis.degree.name Master of Science in Applied Science
thesis.degree.level Masters
thesis.degree.discipline Biology
thesis.degree.grantor Saint Mary's University (Halifax, N.S.)
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