An assessment of anti-staphylococcal, anti-mycobacterial and anti-candidal properties in fungal isolates of the big brown bat (Eptesicus fuscus) microbiome

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dc.contributor.advisor Sit, Clarissa
dc.creator Noujaim, Vanessa
dc.date.accessioned 2020-06-04T17:28:19Z
dc.date.available 2020-06-04T17:28:19Z
dc.date.issued 2020
dc.identifier.uri http://library2.smu.ca/xmlui/handle/01/29372
dc.description 1 online resource (40 pages) : colour illustrations
dc.description Includes abstract and appendices.
dc.description Includes bibliographical references (pages 36-38).
dc.description.abstract Antibiotic resistance is becoming an increasing problem in global health. The emergence of antibiotic-resistant bacterial and fungal infections is expected to increase over the next few years. In an effort to develop therapies to counteract this issue, previously unexplored environmental microbes are assessed in their anti-candidal, anti-staphylococcal and anti-mycobacterial properties. Five strains from the big brown bat microbiome are cross-cultured with three pathogenic strains: Staphylococcus aureus, Mycobacterium smegmatis, and Candida albicans. These pathogenic strains act as proxies for antibiotic-resistant pathogens. Working under the presumption of quorum-sensing occurring between microbes in close proximity, cross-cultures are conducted with the intent of activating dormant pathways. Bat strain growth and phenotypic changes are assessed in these cross-cultures and the possibilities of anti-pathogenic properties in bat strains are determined based on these findings. Two of the five bat strains studied have a strong likelihood of possessing anti-pathogenic properties. The remaining bat strains show promise in further investigations as well, but not to the same extent based on findings. en_CA
dc.description.provenance Submitted by Greg Hilliard (greg.hilliard@smu.ca) on 2020-06-04T17:28:19Z No. of bitstreams: 1 Noujaim_Vanessa_Honours_2020.pdf: 948498 bytes, checksum: 7acd195da382d53ce409e0ec225ab940 (MD5) en
dc.description.provenance Made available in DSpace on 2020-06-04T17:28:19Z (GMT). No. of bitstreams: 1 Noujaim_Vanessa_Honours_2020.pdf: 948498 bytes, checksum: 7acd195da382d53ce409e0ec225ab940 (MD5) Previous issue date: 2020-04-03 en
dc.language.iso en en_CA
dc.publisher Halifax, N.S. : Saint Mary's University
dc.title An assessment of anti-staphylococcal, anti-mycobacterial and anti-candidal properties in fungal isolates of the big brown bat (Eptesicus fuscus) microbiome en_CA
dc.type Text en_CA
thesis.degree.name Bachelor of Science (Honours Biology)
thesis.degree.level Undergraduate
thesis.degree.discipline Biology
thesis.degree.grantor Saint Mary's University (Halifax, N.S.)
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