dc.contributor.advisor |
Brosseau, Christa L. |
|
dc.creator |
Merchant, Soraya T. |
|
dc.date.accessioned |
2016-05-18T13:42:24Z |
|
dc.date.available |
2016-05-18T13:42:24Z |
|
dc.date.issued |
2014 |
|
dc.identifier.other |
QH602 M47 2014 |
|
dc.identifier.uri |
http://library2.smu.ca/handle/01/26492 |
|
dc.description |
xviii, 199, 154, leaves : ill. (chiefly col.) ; 29 cm. |
|
dc.description |
Includes abstract. |
|
dc.description |
Includes bibliographical references (leaves 182-199). |
|
dc.description.abstract |
In recent years, the classification of Alzheimer’s Disease (AD) as a pore-forming disease has been a highly debated topic. It has been postulated that aggregated species, such as amyloid beta (Aβ), derived from a transmembrane protein in neurons, known as amyloid precursor protein (APP), interacts with cell membranes to give toxic effects. One postulated theory suggests that aggregate insertion into cell membranes form non- specific channels that cause a loss of cellular homeostasis. In this investigation, the aim is to produce a defect-free biomimetic model membrane that can be used in future work to validate the AD amyloid pore-hypothesis. The model consists of the deposition of a lipid bilayer by the Langmuir-Blodgett/Langmuir-Schaefer (LB-LS) method onto an electrode surface consisting of silver colloids thus affording the use of the non-invasive, sensitive method of Surface-Enhanced Raman Spectroscopy (SERS). By coupling SERS with electrochemistry (EC-SERS), the membrane properties and quality were monitored. |
en_CA |
dc.description.provenance |
Submitted by Greg Hilliard (greg.hilliard@smu.ca) on 2016-05-18T13:42:24Z
No. of bitstreams: 1
A00002289_Soraya Merchant_MSc Applied Science.pdf: 26195383 bytes, checksum: 4b3f936f7952b67ac9e150cd2e5340fa (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2016-05-18T13:42:24Z (GMT). No. of bitstreams: 1
A00002289_Soraya Merchant_MSc Applied Science.pdf: 26195383 bytes, checksum: 4b3f936f7952b67ac9e150cd2e5340fa (MD5)
Previous issue date: 2014-06-24 |
en |
dc.language.iso |
en |
en_CA |
dc.publisher |
Halifax, N.S. : Saint Mary's University |
|
dc.subject.lcc |
QH602 |
|
dc.subject.lcsh |
Bilayer lipid membranes |
|
dc.subject.lcsh |
Biomimetic materials |
|
dc.subject.lcsh |
Electrochemical analysis |
|
dc.subject.lcsh |
Raman spectroscopy |
|
dc.subject.lcsh |
Raman effect, Surface enhanced |
|
dc.title |
Electrochemical surface-enhanced Raman spectroscopy used in the characterization of Langmuir Blodgett/Langmuir Schaefer biomimetic membranes |
en_CA |
dc.type |
Text |
en_CA |
thesis.degree.name |
Master of Science in Applied Science |
|
thesis.degree.level |
Masters |
|
thesis.degree.discipline |
Chemistry |
|
thesis.degree.grantor |
Saint Mary's University (Halifax, N.S.) |
|