How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga?

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dc.contributor.advisor Frasier, Timothy, 1976-
dc.creator Arif, Suchinta
dc.date.accessioned 2016-12-02T15:38:14Z
dc.date.available 2016-12-02T15:38:14Z
dc.date.issued 2016
dc.identifier.other QL737 C433 A75 2016
dc.identifier.uri http://library2.smu.ca/handle/01/26702
dc.description 115 leaves : ill. (some col.) ; 29 cm
dc.description Includes abstract.
dc.description Includes bibliographical references.
dc.description.abstract The purpose of this project was to understand how genetic factors may be influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga. To assess if variation along candidate genes are influencing cancer susceptibility, I designed primers for the amplification of the p53 gene, and microsatellite regions along seven additional genes: p16, Rb1, BRCA1, BRCA2, PTEN, HPSE2, and FOXO3. Comparing cancer individuals to a control group showed no strong differences with respect to variation along the p53 gene (sequencing analysis) or other candidate loci (microsatellite association analysis), though some patterns warrant further investigation. The degree of inbreeding also showed no relationship with cancer susceptibility. However, bacteria and parasite-induced mortalities were associated with relatively high and low levels of inbreeding, respectively, highlighting the different ways in which inbreeding may be influencing mortality patterns in this population. en_CA
dc.description.provenance Submitted by Greg Hilliard (greg.hilliard@smu.ca) on 2016-12-02T15:38:14Z No. of bitstreams: 1 Arif_Suchinta_MASTERS_2016.pdf: 1143543 bytes, checksum: 94087220d649892921b7441e5109dc95 (MD5) en
dc.description.provenance Made available in DSpace on 2016-12-02T15:38:14Z (GMT). No. of bitstreams: 1 Arif_Suchinta_MASTERS_2016.pdf: 1143543 bytes, checksum: 94087220d649892921b7441e5109dc95 (MD5) Previous issue date: 2016-08-01 en
dc.language.iso en en_CA
dc.publisher Halifax, N.S. : Saint Mary's University
dc.subject.lcc QL737.C433
dc.subject.lcsh White whale -- Saint Lawrence River -- Genetics
dc.subject.lcsh White whale -- Saint Lawrence River -- Mortality
dc.subject.lcsh Cancer in animals -- Genetic aspects
dc.subject.lcsh Cancer in animals -- Susceptibility
dc.title How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? en_CA
dc.type Text en_CA
thesis.degree.name Master of Science in Applied Science
thesis.degree.level Masters
thesis.degree.discipline Biology
thesis.degree.grantor Saint Mary's University (Halifax, N.S.)
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