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Differential effects of cannabis use on event-related potential (ERP)-indexes of cortical inhibition in cannabis users and non-users
Francis, Ashley Morgan
Date: 2021
Type: Text
Abstract:
Cannabis has psychoactive properties and is thought to be associated
with potential structural and functional changes with early and heavy use. Previous
research suggests cannabis users (CU) vs. non-users (NU) have deficits on EEG-derived event-related potentials elicited by paired click and visual Go/NoGo paradigms.
We used these paradigms to examine inhibitory functioning in CUs (n = 14; 9
male) vs. NUs (n = 16, 4 male). Effect sizes suggest CUs had impaired N100 measures of
sensory gating compared to NUs. Additionally, a trend level interaction and latency
findings for the P200 suggested CUs had smaller amplitudes and quicker latencies to
S1 compared to NUs. Go/NoGo findings revealed enhanced P100 amplitudes in CUs (vs.
NUs). No other between-group differences or sex differences were observed. This study
provides further support for cannabis-induced deficits on early-attentional processing as
indexed by the N100 and novel findings regarding enhanced P100 amplitudes to the
Go/NoGo paradigm.
Description:
1 online resource (164 pages) : graphs
Includes abstract and appendices.
Includes bibliographical references (pages 79-112).