Liquid Assisted Grinding for the <i>N</i>-Demethylation of Alkaloids

Awalt, Jon Kyle; Scammels, Peter J.; Singer, Robert D.

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dc.creator	Awalt, Jon Kyle
dc.creator	Scammels, Peter J.
dc.creator	Singer, Robert D.
dc.date.accessioned	2024-09-13T18:25:11Z
dc.date.available	2024-09-13T18:25:11Z
dc.date.issued	2018-08
dc.identifier.issn	2168-0485
dc.identifier.uri	https://dx.doi.org/10.1021/acssuschemeng.8b01393
dc.identifier.uri	http://library2.smu.ca/xmlui/handle/01/32023
dc.description.abstract	A mechanochemical approach has been demonstrated for the selective cleavage of nitrogen–carbon bonds in the <em>N</em>-demethylation of various alkaloids relevant in the pharmaceutical industry. This methodology employs a range of so-called “liquid additives” used in microliter quantities in liquid assisted grinding rather than “solvents” used in solution phase reactions. Green liquid additives such as alcohols, water, PEG and ionic liquids as well as a nonchemical, mechanical approach for the generation of nanoscale Fe<sup>0</sup> dust significantly improve the green attributes of the <em>N</em>-demethylation process.</span></p>	en_CA
dc.description.provenance	Submitted by Anna Labrador (anna.labrador@smu.ca) on 2024-09-13T18:25:11Z No. of bitstreams: 1 Singer_Robert_D._2018.pdf: 2173211 bytes, checksum: 916cc8a50a6e8d9f6fe688c2c015bfd4 (MD5)	en
dc.description.provenance	Made available in DSpace on 2024-09-13T18:25:11Z (GMT). No. of bitstreams: 1 Singer_Robert_D._2018.pdf: 2173211 bytes, checksum: 916cc8a50a6e8d9f6fe688c2c015bfd4 (MD5) Previous issue date: 2018-08	en
dc.description.sponsorship	Published version	en_CA
dc.language.iso	en	en_CA
dc.publisher	American Chemical Society	en_CA
dc.relation.uri	https://dx.doi.org/10.1021/acssuschemeng.8b01393
dc.rights	<p><a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons 4.0 License</a></p>
dc.subject.lcsh	Alkaloids
dc.subject.lcsh	Mechanical chemistry
dc.title	Liquid Assisted Grinding for the <i>N</i>-Demethylation of Alkaloids	en_CA
dc.type	Text	en_CA
dcterms.bibliographicCitation	ACS Sustainable Chemistry & Engineering, 6 (8), 10052-10057. (2018)	en_CA