dc.contributor.advisor |
Singer, Robert D., 1964- |
|
dc.creator |
Awalt, Jon Kyle |
|
dc.date.accessioned |
2016-06-10T13:49:08Z |
|
dc.date.available |
2016-06-10T13:49:08Z |
|
dc.date.issued |
2016 |
|
dc.identifier.uri |
http://library2.smu.ca/handle/01/26518 |
|
dc.description |
1 online resource (x, 48 p.) : ill. (some col.) |
|
dc.description |
Includes abstract. |
|
dc.description |
Includes bibliographical references (p. 42-48). |
|
dc.description.abstract |
The N-demethylation of naturally occurring opiate compounds is a necessary step in the synthesis of many pseudo-opioid pharmaceuticals. Such drugs have gained recent media attention in the fight against opiate addiction; hence, the ability to synthesize them efficiently is important. This work aims to improve the N-demethylation of alkaloid precursors through the use of zero valent nanoscale iron in a modified Polonovski reaction. Initial studies performed on dextromethorphan indicate that yields of the demethylated product using a 10 mol % loading of zero valent nanoscale iron are comparable to those achieved by using a stoichiometric amount of commercially available iron (0) dust. The preparation of zero valent nanoscale iron particles and their use in the N-demethylation of dextromethorphan will be described. |
en_CA |
dc.description.provenance |
Submitted by Greg Hilliard (greg.hilliard@smu.ca) on 2016-06-10T13:49:08Z
No. of bitstreams: 1
Awalt_Jon_Honours_2016.pdf: 1445003 bytes, checksum: d44f2d5008cb50ea714a4d79cb221444 (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2016-06-10T13:49:08Z (GMT). No. of bitstreams: 1
Awalt_Jon_Honours_2016.pdf: 1445003 bytes, checksum: d44f2d5008cb50ea714a4d79cb221444 (MD5)
Previous issue date: 2016-04-21 |
en |
dc.language.iso |
en |
en_CA |
dc.publisher |
Halifax, N.S. : Saint Mary's University |
|
dc.title |
N-demethylation of alkaloids using nanoscale zero valent iron |
en_CA |
dc.type |
Text |
en_CA |
thesis.degree.name |
Bachelor of Science (Honours Chemistry) |
|
thesis.degree.level |
Undergraduate |
|
thesis.degree.discipline |
Chemistry |
|
thesis.degree.grantor |
Saint Mary's University (Halifax, N.S.) |
|