dc.creator |
Killorn, Julia |
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dc.date.accessioned |
2017-05-26T13:42:14Z |
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dc.date.available |
2017-05-26T13:42:14Z |
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dc.date.issued |
2017-04-25 |
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dc.identifier.uri |
http://library2.smu.ca/handle/01/26978 |
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dc.description.abstract |
A modified Polonovski reaction using an iron (0) catalyst has been shown to be an effective means of N-demethylating opiate and pseudo-opiate compounds.1 It has also been demonstrated that the choice of solvent in this reaction is of major significance as solvent effects play a large role in yields of N-demethylated product; isolated yields ranged from 59% (methanol) to 97% (chloroform). The current work aims to utilize the highly polar yet non-coordinating properties of ionic liquids as a reaction solvent. Ionic liquid solvents possess the added benefit of maximizing the solubility of the N-oxide hydrochloride starting material necessary for the modified Polonovski reaction. Use of commercial magnetite and rust nanoparticles as catalysts in ionic liquids for the modified Polonovski reaction will be discussed. |
en_CA |
dc.description.provenance |
Submitted by Greg Hilliard (greg.hilliard@smu.ca) on 2017-05-26T13:42:14Z
No. of bitstreams: 1
Killorn_Julia_Honours_2017.pdf: 1455457 bytes, checksum: b30f088390f9f59308ae7f40b908c4a6 (MD5) |
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dc.description.provenance |
Made available in DSpace on 2017-05-26T13:42:14Z (GMT). No. of bitstreams: 1
Killorn_Julia_Honours_2017.pdf: 1455457 bytes, checksum: b30f088390f9f59308ae7f40b908c4a6 (MD5)
Previous issue date: 2017-04-25 |
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dc.language.iso |
en |
en_CA |
dc.title |
Modified polonovski reactions in ionic liquid solvents |
en_CA |
dc.type |
Text |
en_CA |