Regulation of inflammation during pseudomonas aeruginosa lung infection : a role of AIM2 and RCAN1

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dc.contributor.advisor Sun, Genlou
dc.creator Pang, Zheng
dc.date.accessioned 2023-02-15T17:43:51Z
dc.date.available 2023-02-15T17:43:51Z
dc.date.issued 2015-07-28
dc.identifier.uri http://library2.smu.ca/xmlui/handle/01/31347
dc.description 1 online resource (vi, 112 pages) : illustrations, charts (some colour), graphs
dc.description Includes abstract.
dc.description Includes bibliographical references (28-47, 69-75, 98-104, 108-112).
dc.description.abstract <i>Pseudomonas aeruginosa</i> is an opportunistic bacterial pathogen that is an important cause of infection among immunocompromised individuals. <i>P. aeruginosa</i> chronically infects cystic fibrosis patients, leading to declined pulmonary function and increased morbidity and mortality. Host innate immune system employs a variety of pattern recognition receptors (PRRs) to detect the conserved molecular patterns on invading <i>P. aeruginosa</i>. In healthy individuals, activation of these PRRs triggers a complex of downstream signalling pathways that induce production of various proinflammatory cytokines and efficiently eliminates <i>P. aeruginosa</i> from the host. However, dysregulation of these signalling pathways increases the susceptibility of the host to bacterial infection. Herein we identify that AIM2 inflammasome, an intracellular dsDNA sensor, is functionally redundant in IL-1β production and caspase-1 activation during <i>P. aeruginosa</i> lung infection. Furthermore, we reveal regulator of calcineurin-1 as a novel negative regulator of the TLR-MyD88-dependent signalling pathway in a mouse model of acute pneumonia using <i>P. aeruginosa</i> lipopolysaccharide. These findings improve our understanding of the molecular mechanisms of host defense against <i>P. aeruginosa</i> in innate immunity. en_CA
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dc.description.provenance Made available in DSpace on 2023-02-15T17:43:51Z (GMT). No. of bitstreams: 1 Pang_Zheng_MASTERS_2015.pdf: 1102930 bytes, checksum: 210f5ee812ea8918078347ce41ee8bf2 (MD5) Previous issue date: 2015-07-28 en
dc.language.iso en en_CA
dc.publisher Halifax, N.S. : Saint Mary's University
dc.subject.lcsh Pseudomonas aeruginosa infections
dc.subject.lcsh Inflammation -- Immunological aspects
dc.subject.lcsh Lungs -- Infections
dc.subject.lcsh Cystic fibrosis -- Patients
dc.title Regulation of inflammation during pseudomonas aeruginosa lung infection : a role of AIM2 and RCAN1 en_CA
dc.type Text en_CA
thesis.degree.name Master of Science in Applied Science
thesis.degree.level Masters
thesis.degree.discipline Biology
thesis.degree.grantor Saint Mary's University (Halifax, N.S.)
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